UJI EFEKTIVITAS SEDIAAN TOPIKAL DAN ORAL DAUN JATI (Tectona grandis) TERHADAP MORFOLOGI LUKA BAKAR MENCIT JANTAN

Ani Purwanti, Joko Widiyanto, Cicilia Novi Primiani

Abstract


This study aims to determine the effect of topical and oral preparations of teak leaves (T. grandis) on the extent of male mice burns. The study was conducted in April-July 2018, using an experimental approach and a completely randomized design with 5 treatments and 5 repetitions. The experimental animals used in the study were male mice aged 2-3 months and weighing 20-38 grams. The treatments used included M0 (control treatment), M1 (treatment with synthetic ointment), M2 (treatment with topical preparations of 5% teak leaf ointment), M3 (treatment with oral preparations of teak leaves at 10 mg flavonoid / gBB) and M4 (treatment with topical preparations of 5% teak leaf ointment and oral preparations of teak leaves dose 10 mg flavonoid / gBB). Measuring the area of burns was done once every 4 days using an accuracy of 0.02 mm calipers. The results showed that the five treatments had different effects on the extent of male mice burns. The fastest narrowing of burns was M1 and M2 treatment which left a wound area of 0 cm on day 29.


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References


Aggraeni, E. (2017). Penyusunan Buku Pengayaan Biologi SMA Berdasarkan Hasil Penelitian Identifikasi Senyawa Flavonoid Famili Lamiceae. Skripsi. Madiun: FKIP Pendidikan Biologi

Arief, I. I., Suryati, T., Afiyah, D. N., & Wardhani, D. P. (2014). Physicochemical and organoleptic of beef sausages with teak leaf extract (Tectona grandis) addition as preservative and natural dye. International Food Research Journal, 21(5), 2033.

Desiyana, L. S., Husni, M. A., & Zhafira, S. (2016). Uji Efektivitas Sediaan Gel Fraksi Etil Asetat Daun Jambu Biji (Psidium Guajava Linn) Terhadap Penyembuhan Luka Terbuka Pada Mencit (Mus Musculus). Jurnal natural, 16(2).

Fuadi, M. I., Elfiah, U., & Misnawi, M. (2015). Jumlah Fibroblas pada Luka Bakar Derajat II pada Tikus dengan Pemberian Gel Ekstrak Etanol Biji Kakao dan Silver Sulfadiazine (The Total Fibroblast on the Second Degree Burns of Rats after Treatment using Ethanolic Extract of Cocoa Beans). Pustaka Kesehatan, 3(2), 244-248

Izzati, U. Z. (2015). Efektivitas Penyembuhan Luka Bakar Salep Ekstrak Etanol Daun Senggani (Melastoma Malabathricum L.) Pada Tikus (Rattus Norvegicus) Jantan Galur Wistar. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 3(1).

Majumdar, M. (2005). Evaluation of Tectona grandis leaves for wound healing activity (Doctoral dissertation, RGUHS).

Suharyanto (2018). 3 Proses Penyembuhan Luka dan Penjelasannya. (Online), (https://dosenbiologi.com/biolo gi-dasar/proses-penyembuhan-luka, diunduh 05 April 2018)

Wibowo N. A. (2017). Bagaimana Proses Penyembuhan Luka Pada Manusia?. https://www.dictio.id/t/bagaima na-proses-penyembuhan-luka-pada-manusia/14731 (di unduh pada tanggal 6 Agustus 2018)

Yuliani, N. S., & Lenda, V. (2015).Pengaruh ekstrak Daun C. Odorata Terhadap Proses Kesembuhan Luka Insisi Pada Tikus Sprague-Dawley. Jurnal Kajian Veteriner Desember, 3(2), 93-99.


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