PENGARUH PEMBERIAN SIMPLISIA DAUN KELOR (Moringa oleifera) TERHADAP STRUKTUR JARINGAN GINJAL MENCIT (Mus muculus)

Novanda Eka Saputra, Ani Sulistyarsi

Abstract


This study aims to determine the effect of oral simplicia preparation of Moringa oleifera leaves on kidney histological of female mice. The study was conducted in March-June 2019, using an experimental approach and a completely randomized design with 4 treatments and 6 repetitions. The experimental animals used in the study were female mice aged 12-16 weeks and weighing 30-40 grams. The treatments used included P0 (control treatment), P1 (treatment with simplicia moringa oleifera leaves 126 gram/20 kg weight), P2 (treatment with simplicia moringa oleifera 0,168 gram/20 kg weight) P3 (treatment with simplicia moringa oleifera 0,210 gram/20 kg BB weight). Kidneys of all mice were collected on day 18th, following treatment. Histological preparations for was made and stained with haematoxylin eosin. Data were analyzed using one way. has the same average significantly and does not affect the glomerular diameter of the kidneys. Glomerular diameter in all treatment groups showed that the glomerular arrangement was normal. The glomerular diameter between the control group and group P1, P2, and P3 did not experience a significant difference. This indicates that the function of kidney filtration in the glomerulus is still normal kidney histological in all treatment groups no histological damage or normal was found.

 

Keywords: Hitology, Kidneys, glomerular  Simplicia, Mice


Full Text:

PDF(365-370)

References


Bata, M. H., Wijaya, S., & Setiawan, H. K. (2018). Standarisasi Simplisia Kering Daun Kelor (Moringa oleifera) Dari Tiga Daerah Berbeda. Jurnal Farmasi Sains dan Terapan, 5(1): 45-52.

Charoensin, S. (2014). Antioxidant and anticancer activities of Moringa oleifera leaves. Journal of Medicinal Plants Research, 8(7), 318-325

Gopalakrishnan, L., Doriya, K., & Kumar,D. S. (2016). Moringa oleifera: A review on nutritive importance and its medicinal application. FoodScience and Human Wellness, 5(2),49-56.

Edoga, C.O, Njoku, O.O, Amadi, E.N.; Okeke, J.J. (2013). Blood sugar lowering effect of Moringa oleifera Lam in albino rats. Int. J. Sci. Technol. 3:88–90.

Handani, A. R., Salim, M. N., Harris, A., & Budiman, H. (2015). Pengaruh Pemberian Kacang Panjang (Vigna Unguicula tterhadap Struktur Mikroskopis Ginjal Mencit (Mus Musculus) Yang Diinduksi Aloksan. Jurnal Medika Veterinaria, 9(1).

Hastuti, N. A. R., Winarsih, S., & Dwijayasa, P. M. (2018). Pengaruh Ekstrak Air Daun Kelor terhadap Kadar Leptin dan Malondialdehyde Lemak Visceral Tikus Wistar yang Dipapar Depo Medroxyprogesterone Acetate. Journal of Issues in Midwifery, 2(1).

Jung, I.L. (2014) Soluble extract from Moringa oleifera Leaves with a new anticancer activity. PLoS ONE 9, e95492.

Khoiriyah, S. I., Athiroh, N., & Zayadi, H. (2019). Kajian Subkronik 28 Hari Ekstrak Metanolik Scurrula atropurpurea terhadap Kadar Laktat Dihidrogenase Tikus Betina.Biosaintropis(Bioscience-Tropic), 4(2): 13-19.

Kusuma, D., Dewi, A. K., & Hermanto, B. (2018). The Effect of Graded Doses of Oral Trihexyphenidyl on Lumen Diameter of Mus musculus Renal Kidney. eJournal Kedokteran Indonesia

Kumar, S.; Pandey, A.K. (2013) Chemistry and biological activities of flavonoids: An overview. Sci. World J. 162750.

Manach, C., Morand, C., Demigné, C., Texier, O., Régérat, F., & Rémésy, C. (1997). Bioavailability of rutin and quercetin in rats.FEBS letters, 409(1): 12-16.

Purnamasari, P., Purnawati, R. D., & Susilaningsih, N. (2018). Pengaruh Ekstrak Daun Sukun (Artocarpus Altilis) dan Madu Terhadap Gambaran Mikroskopis Ginjal Tikus Wistar yang Diinduksi Dietilnitrosamin (Doctoral dissertation, Faculty of Medicine).

Puspitasari, D. (2015). Uji toksisitas subkronik ekstrak air daun katuk (Sauropus androgynus) terhadap histologi dan berat ginjal tikus putih betina (Rattus norvegycus) (Doctoral dissertation, Universitas Islam Negeri Maulana Malik Ibrahim).

Roslizawaty., Budiman, H., Laila, H dan Herrialfian. (2013). Pengaruh Ekstrak Etanol Sarang Semut (Myrmecodia sp.) Terhadap Gambara Histopatologi Ginjal Mencit Jantan (Mus musculus L.) Jantan yang Hiperurisemia. Jurnal Medika Veterinaria. 7(2).

Sulistyarsi, A., & Cahyani, F. M. (2019). Potensi Ekstrak Daun Kamboja Putih dari Madiun dan Magetan sebagai Penghambat Pertumbuhan Bakteri Salmonella Typhosa (In Vitro). In Prosiding Seminar Nasional Hasil Penelitian LPPM Universitas PGRI Madiun (pp. 219-227).

Vergara-Jimenez, M., Almatrafi, M., & Fernandez, M. (2017). Bioactive components in Moringa Oleifera leaves protect against chronic disease. Antioxidants, 6(4): 91.

Wang, Z., Zhai, D., Zhang, D., Bai, L., Yao, R., Yu, J., . . . Yu, C. (2017). Quercetin Decreases Insulin Resistance in a Polycystic Ovary Syndrome Rat Model by Improving Inflammatory Microenvironment. Reproductive Sciences, 24(5): 682-690

Widowati, I., Efiyati, S., & Wahyuningtyas, S. (2014). Uji Aktivitas Antibakteri Ekstrak Daun Kelor (moringa oleifera) terhadap Bakteri Pembusuk Ikan Segar (Pseudoonas Aeruginosa). Pelita-Jurnal Penelitian Mahasiswa UNY, 9(02).


Refbacks

  • There are currently no refbacks.